Semax

Research Use Only Disclaimer

Semax is sold strictly for laboratory, academic and institutional research. It is not for human or animal consumption, injection, or any therapeutic, diagnostic or veterinary use.

PCH Peptides does not provide dosage, administration or usage guidance. The product is supplied exclusively for qualified researchers working in controlled laboratory environments.

What Is Semax?

Semax is a synthetic heptapeptide composed of seven amino acid residues arranged in the sequence Met-Glu-His-Phe-Pro-Gly-Pro.

It is structurally derived from a fragment of adrenocorticotropic hormone (ACTH), a naturally occurring peptide hormone involved in endocrine signalling.

Semax contains the ACTH(4-7) sequence, Met-Glu-His-Phe, followed by an additional Pro-Gly-Pro fragment.

This structural modification was developed to influence peptide stability and resistance to enzymatic degradation compared with the original short ACTH fragment.

Although Semax is derived from an ACTH sequence, it is structurally distinct from the full-length hormone and is not generally characterized by the adrenal-stimulating activity of native ACTH.

Researchers investigate Semax in controlled laboratory models involving neuropeptide chemistry, neuronal cellular responses, peptide stability and molecular signalling pathways.

Some preclinical studies have examined Semax in relation to brain-derived neurotrophic factor (BDNF) expression and other molecular markers associated with neuronal signalling.

Semax is also frequently compared with Selank, another synthetic heptapeptide containing a Pro-Gly-Pro sequence.

Although these peptides share a structural fragment, Semax is derived from an ACTH-related sequence, while Selank is based on the naturally occurring peptide tuftsin.

For additional background on peptide structures and laboratory applications, explore the What Are Peptides? Research Guide.

Semax 10mg Specifications

Semax in Laboratory Research

Semax is investigated in biochemical and cellular research involving neuropeptide signalling, molecular characterization, peptide stability and neuronal cell models.

Neuropeptide Signalling Research

Semax is studied in experimental models involving peptide-associated neuronal signalling and molecular interactions.

Researchers investigate its structural characteristics and potential relationships with cellular pathways involved in neuronal communication.

Laboratory studies may examine changes in molecular markers, gene expression and signalling responses under controlled experimental conditions.

Its ACTH-derived amino acid sequence makes it relevant to comparative research involving naturally occurring regulatory peptides and synthetic analogues.

The precise molecular mechanisms associated with Semax remain subjects of scientific investigation.

Brain-Derived Neurotrophic Factor (BDNF) Research

Brain-derived neurotrophic factor is a protein involved in neuronal development, cellular maintenance and signalling.

Some preclinical studies have investigated Semax in experimental models involving BDNF expression and related molecular pathways.

Researchers may examine changes in neurotrophic factor-associated gene expression, protein levels and cellular responses.

These studies contribute to the characterization of peptide-related molecular signalling in neuronal research models.

However, findings from cell-culture and animal experiments do not establish clinical effectiveness or safety for human use.

ACTH Fragment Research

Adrenocorticotropic hormone is a peptide hormone derived from the proopiomelanocortin (POMC) precursor protein.

Semax incorporates the ACTH(4-7) sequence, representing a short region of the parent hormone.

Researchers investigate this fragment to better understand how specific amino acid sequences influence peptide structure and molecular interactions.

Comparative studies may examine Semax alongside other ACTH-derived peptide fragments.

Its sequence differs substantially from full-length ACTH, and it should not be assumed to possess the same endocrine activity.

Peptide Stability and Molecular Characterization

Semax contains a Pro-Gly-Pro sequence added to the ACTH-derived fragment.

This structural feature is relevant to laboratory investigations involving peptide stability, molecular structure and enzymatic degradation.

Researchers may examine the compound’s chemical properties, degradation characteristics and analytical profile under controlled conditions.

These studies can contribute to understanding how amino acid sequence modifications influence synthetic peptide behaviour.

Comparative Research With Selank

Semax and Selank are both synthetic heptapeptides containing a Pro-Gly-Pro fragment.

However, their parent peptide sequences differ.

Semax is based on ACTH(4-7), while Selank is derived from tuftsin.

Researchers compare these compounds in neuropeptide chemistry, molecular stability and cellular signalling studies.

For additional information about the related compound, review the Selank research peptide product page.

Certificate of Analysis

PCH Peptides provides batch-specific analytical documentation for its Semax research material.

The PCH Peptides COA Library currently lists one Certificate of Analysis and one endotoxin report for Semax.

Researchers should review the applicable batch Certificate of Analysis to confirm compound identity, HPLC purity percentage and other available analytical findings.

The exact purity percentage should be taken directly from the current batch documentation rather than assumed from general product specifications.

The endotoxin report should be reviewed separately because endotoxin testing and HPLC purity testing measure different aspects of material quality.

Batch-specific documentation supports laboratory quality assessment, analytical verification and material traceability.

For additional information about research material classifications and documentation, review the Research Use Only Peptides Guide.

Storage and Handling

Keep the Semax vial sealed until required for an authorized laboratory workflow.

Store the lyophilized research material in a cold, dry environment protected from moisture, excessive heat and direct light.

Follow the storage temperature and handling recommendations provided on the product label and applicable batch-specific documentation.

Appropriate storage conditions help maintain the integrity of synthetic peptides during laboratory handling and molecular analysis.

Avoid using material from containers with damaged packaging, broken seals or uncertain identification.

Reconstitution Solution is available separately for suitable laboratory research applications, subject to compatibility with the intended analytical workflow.

Researchers seeking general information about lyophilized peptide preparation can review the educational article on how peptide reconstitution works.

Related Research Materials

Laboratories investigating neuropeptide chemistry, neuronal cellular signalling and short regulatory peptides may also examine other synthetic research compounds.

• Selank – A synthetic heptapeptide derived from the naturally occurring peptide tuftsin. It contains a Pro-Gly-Pro sequence and is investigated in regulatory peptide chemistry, molecular signalling and peptide stability research.
• DSIP – Delta Sleep-Inducing Peptide, a synthetic nonapeptide investigated in neuropeptide chemistry, receptor-ligand screening and molecular characterization.
• Pinealon – A synthetic tripeptide with the sequence Glu-Asp-Arg (EDR), studied in short regulatory peptide chemistry, neuronal cell models and molecular stability research.
• Epithalon – A synthetic tetrapeptide containing Ala-Glu-Asp-Gly (AEDG), investigated in laboratory models involving cellular regulation, gene expression and peptide characterization.

These compounds differ in molecular structure, amino acid composition and experimental research applications.

Semax and Selank share the Pro-Gly-Pro sequence, while DSIP, Pinealon and Epithalon are investigated in other areas of neuropeptide and regulatory peptide research.

Researchers can explore additional compounds through the PCH Peptides research peptide catalog.

Frequently Asked Questions

What is Semax peptide?

Semax is a synthetic heptapeptide derived from a short fragment of adrenocorticotropic hormone (ACTH).

It consists of seven amino acids arranged in the sequence Met-Glu-His-Phe-Pro-Gly-Pro.

Researchers investigate Semax in laboratory studies involving neuropeptide chemistry, molecular characterization and neuronal signalling.

What is the Semax amino acid sequence?

Semax contains the seven-amino-acid sequence Met-Glu-His-Phe-Pro-Gly-Pro.

Its single-letter sequence is MEHFPGP.

The peptide has a molecular formula of C37H51N9O10S and an approximate molecular weight of 813.9 g/mol.

What is Semax derived from?

Semax is based on the ACTH(4-7) fragment of adrenocorticotropic hormone.

The original four-amino-acid sequence, Met-Glu-His-Phe, is extended with Pro-Gly-Pro to create the seven-residue synthetic peptide.

The additional sequence is associated with modifications to peptide stability and susceptibility to enzymatic degradation.

What is Semax used for in research?

Semax is investigated in preclinical laboratory studies involving neuropeptide signalling, neuronal cell models, molecular stability and neurotrophic factor-associated gene expression.

Researchers have also examined its relationship with BDNF expression in experimental systems.

These applications remain experimental and do not establish therapeutic safety or effectiveness for human use.

What is the difference between Semax and Selank?

Both Semax and Selank are synthetic heptapeptides that contain a Pro-Gly-Pro fragment.

Semax is based on an ACTH-derived peptide sequence, while Selank is derived from tuftsin.

Their different parent sequences result in distinct molecular structures and experimental research profiles.

Researchers investigate both compounds in overlapping areas of neuropeptide chemistry and molecular signalling.

Does Semax contain ACTH?

Semax contains a short amino acid sequence derived from ACTH, but it is not the same compound as full-length adrenocorticotropic hormone.

Semax consists of the ACTH(4-7) fragment with an added Pro-Gly-Pro sequence.

It should not be assumed to possess the same endocrine activity as native ACTH.

Is Semax studied in BDNF research?

Yes. Some preclinical investigations have examined Semax in relation to brain-derived neurotrophic factor (BDNF) expression and associated neuronal signalling pathways.

These studies involve experimental research models and do not establish clinical effectiveness in humans.

What is the molecular weight of Semax?

Semax has an approximate molecular weight of 813.9 g/mol and a molecular formula of C37H51N9O10S.

These specifications refer to the reference peptide structure. Any salt-form or formulation-specific differences should be verified against the applicable batch documentation.

What size does Semax come in?

PCH Peptides supplies Semax as a 10mg lyophilized research material in a single vial.

The product is intended exclusively for qualified laboratory, academic and institutional research applications.

Is Semax batch tested?

The PCH Peptides COA Library lists one Certificate of Analysis and one endotoxin report for Semax.

Researchers should review the applicable batch documentation to verify compound identity, purity and available analytical testing results.

Available certificates can be accessed through the COA Library.

How should Semax be stored?

Semax should remain sealed and protected from moisture, excessive heat and direct light.

Follow the storage temperature and handling recommendations printed on the product label and any applicable batch-specific documentation.

Appropriate storage helps maintain the integrity of lyophilized peptide research materials.

Is Semax intended for human or animal use?

No. Semax is supplied strictly for laboratory, academic and institutional research.

It is not intended for human or animal consumption, injection, therapeutic applications, diagnosis or veterinary use.

For additional information about research material classifications, review the Research Use Only Peptides Guide.

Do you provide dosage instructions for Semax?

No. PCH Peptides does not provide dosage, administration or usage protocols. Semax is supplied exclusively for qualified research use only.